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Explaining ME/CFS? Prusty / Naviaux Study Ties Infections to Energy Breakdowns

Datum: 26.04.2020 Kategorie: 07 Fatigatio e.V. Autor: MKK (kanter)

Unexpected synchronies are always a good sign. Many, of course, are familiar with Bob Naviaux, MD, PhD from the University of California, San Diego (UCSD). Naviaux’s metabolomic work and his Cell Danger Response (CDR) hypothesis have opened up new possible ways of understanding ME/CFS, autism and other diseases.   Naviaux is best known for his metabolomic work, but what most people don’t know is that Naviaux is also a Salk-trained virologist, who invented some early retroviral gene transfer vectors, and was trained, to boot, in natural killer cell biology – a key topic in ME/CFS.

Bhupesh Prusty, PhD of the University of Würzburg in Germany, is newer on the scene but has been raising eyebrows with his proposal that herpesviruses like HHV-6 (and other viruses as well) may be knocking the mitochondria in ME/CFS patients for a loop.

The two authors – Prusty and Naviaux were the co-senior authors who conceived the project – teamed together to attempt to answer a question that’s been plaguing patients, doctors and researchers for years: how to tie together the energy problems in ME/CFS with the infectious onset that so many patients experience. Coming from two separate fields, Bhupesh Prusty and Bob Naviaux may have come up with a way.

They chose, what else, herpesviruses (HHV-6, HHV-7) to test their hypothesis.